The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.
Identifieur interne : 000267 ( Main/Exploration ); précédent : 000266; suivant : 000268The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.
Auteurs : Alyce C. Russell [Australie] ; Mirna Šimurina [Croatie] ; Monique T. Garcia [Australie] ; Mislav Novokmet [Croatie] ; Youxin Wang [République populaire de Chine] ; Igor Rudan [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Gordan Lauc [Australie] ; Meghan G. Thomas [Australie] ; Wei Wang [Australie]Source :
- Glycobiology [ 1460-2423 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cytotoxicité à médiation cellulaire dépendante des anticorps (génétique), Femelle, Glycomique, Glycosylation, Humains, Immunoglobuline G (sang), Maladie de Parkinson (anatomopathologie), Maladie de Parkinson (génétique), Maladie de Parkinson (sang), Marqueurs biologiques (sang), Mâle, Polyosides (sang), Sujet âgé, Évolution de la maladie.
- MESH :
- anatomopathologie : Maladie de Parkinson.
- génétique : Cytotoxicité à médiation cellulaire dépendante des anticorps, Maladie de Parkinson.
- sang : Immunoglobuline G, Maladie de Parkinson, Marqueurs biologiques, Polyosides.
- Adulte d'âge moyen, Femelle, Glycomique, Glycosylation, Humains, Mâle, Sujet âgé, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers, Immunoglobulin G, Polysaccharides.
- blood : Parkinson Disease.
- genetics : Antibody-Dependent Cell Cytotoxicity, Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Disease Progression, Female, Glycomics, Glycosylation, Humans, Male, Middle Aged.
Abstract
The use of the emerging "omics" technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson's disease, it is essential that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-inflammatory and pro-inflammatory effects, and the N-glycosylation of the fragment crystallizable portion of IgG is involved in this process. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson's disease. Ninety-four community-based individuals with Parkinson's disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a "normally" aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically significant differences (P < 8.06 × 10-4) between Parkinson's disease cases and healthy controls. Out of the seven significantly different glycan peaks, four were selected by Akaike's Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a specificity of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fcγ-RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade inflammation in individuals with Parkinson's disease.
DOI: 10.1093/glycob/cwx022
PubMed: 28334832
Affiliations:
- Australie, Croatie, Royaume-Uni, République populaire de Chine
- Écosse
- Édimbourg
- Université d'Édimbourg
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Le document en format XML
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Russell</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Simurina, Mirna" sort="Simurina, Mirna" uniqKey="Simurina M" first="Mirna" last="Šimurina">Mirna Šimurina</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacica 1, 10000, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovacica 1, 10000, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Monique T" sort="Garcia, Monique T" uniqKey="Garcia M" first="Monique T" last="Garcia">Monique T. Garcia</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Novokmet, Mislav" sort="Novokmet, Mislav" uniqKey="Novokmet M" first="Mislav" last="Novokmet">Mislav Novokmet</name><affiliation wicri:level="1"><nlm:affiliation>Genos Glycoscience Research Laboratory, Hondlova 2/11, I.V. kat, 10000, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Genos Glycoscience Research Laboratory, Hondlova 2/11, I.V. kat, 10000, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Youxin" sort="Wang, Youxin" uniqKey="Wang Y" first="Youxin" last="Wang">Youxin Wang</name><affiliation wicri:level="1"><nlm:affiliation>Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Fengtai Qu, Beijing Shi, 100054, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Fengtai Qu, Beijing Shi, 100054</wicri:regionArea><wicri:noRegion>100054</wicri:noRegion></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Global Health Research, The Usher Institute, University of Edinburgh, 9 Little France Road, Edinburgh, EH16 4UX</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Lauc, Gordan" sort="Lauc, Gordan" uniqKey="Lauc G" first="Gordan" last="Lauc">Gordan Lauc</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Meghan G" sort="Thomas, Meghan G" uniqKey="Thomas M" first="Meghan G" last="Thomas">Meghan G. Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Parkinson's Centre, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation wicri:level="1"><nlm:affiliation>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027</wicri:regionArea><wicri:noRegion>WA 6027</wicri:noRegion></affiliation></author></analytic><series><title level="j">Glycobiology</title><idno type="eISSN">1460-2423</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antibody-Dependent Cell Cytotoxicity (genetics)</term><term>Biomarkers (blood)</term><term>Disease Progression</term><term>Female</term><term>Glycomics</term><term>Glycosylation</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Polysaccharides (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Cytotoxicité à médiation cellulaire dépendante des anticorps (génétique)</term><term>Femelle</term><term>Glycomique</term><term>Glycosylation</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Maladie de Parkinson (anatomopathologie)</term><term>Maladie de Parkinson (génétique)</term><term>Maladie de Parkinson (sang)</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Polyosides (sang)</term><term>Sujet âgé</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Immunoglobulin G</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antibody-Dependent Cell Cytotoxicity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytotoxicité à médiation cellulaire dépendante des anticorps</term><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term><term>Maladie de Parkinson</term><term>Marqueurs biologiques</term><term>Polyosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Glycomics</term><term>Glycosylation</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Glycomique</term><term>Glycosylation</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The use of the emerging "omics" technologies for large scale population screening is promising in terms of predictive, preventive and personalized medicine. For Parkinson's disease, it is essential that an accurate diagnosis is obtained and disease progression can be monitored. Immunoglobulin G (IgG) has the ability to exert both anti-inflammatory and pro-inflammatory effects, and the N-glycosylation of the fragment crystallizable portion of IgG is involved in this process. This study aimed to determine whether the IgG glycome could be a candidate biomarker for Parkinson's disease. Ninety-four community-based individuals with Parkinson's disease and a sex-, age- and ethnically-matched cohort of 102 individuals with mixed phenotypes, representative of a "normally" aged Caucasian controls, were investigated. Plasma IgG glycans were analyzed by ultra-performance liquid chromatography. Overall, seven glycan peaks and 11 derived traits had statistically significant differences (P < 8.06 × 10-4) between Parkinson's disease cases and healthy controls. Out of the seven significantly different glycan peaks, four were selected by Akaike's Information Criterion to be included in the logistic regression model, with a sensitivity of 87.2% and a specificity of 92.2%. The study suggested that there may be a reduced capacity for the IgG to inhibit Fcγ-RIIIa binding, which would allow an increased ability for the IgG to cause antibody-dependent cell cytotoxicity and a possible state of low-grade inflammation in individuals with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Croatie</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Russell, Alyce C" sort="Russell, Alyce C" uniqKey="Russell A" first="Alyce C" last="Russell">Alyce C. Russell</name></noRegion><name sortKey="Garcia, Monique T" sort="Garcia, Monique T" uniqKey="Garcia M" first="Monique T" last="Garcia">Monique T. Garcia</name><name sortKey="Lauc, Gordan" sort="Lauc, Gordan" uniqKey="Lauc G" first="Gordan" last="Lauc">Gordan Lauc</name><name sortKey="Thomas, Meghan G" sort="Thomas, Meghan G" uniqKey="Thomas M" first="Meghan G" last="Thomas">Meghan G. Thomas</name><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name></country><country name="Croatie"><noRegion><name sortKey="Simurina, Mirna" sort="Simurina, Mirna" uniqKey="Simurina M" first="Mirna" last="Šimurina">Mirna Šimurina</name></noRegion><name sortKey="Novokmet, Mislav" sort="Novokmet, Mislav" uniqKey="Novokmet M" first="Mislav" last="Novokmet">Mislav Novokmet</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Youxin" sort="Wang, Youxin" uniqKey="Wang Y" first="Youxin" last="Wang">Youxin Wang</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name></region><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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